A novel technology
Seek & Heal™ targeting
Seek & Heal™ targeting represents
a novel
technology in drug targeting of foreign cells.
The technology is built around particles
containing a pharmaceutical substance.
that selectively adhere to foreign cells in
the human body.
Patent has been applied for..
Seek & Heal™ drug targeting represent true
drug targeting as the particles are selectively
concentrated close to foreign cells.
Biomimetic
The invention was inspired by a
hypothesis
of
how white
blood cells
identifies
foreign
cells.
Globally uniqueness
At present, drug targeting are centered around
use of receptor ligands, which are large and
expensive molecules. Drug targeting is there-
fore used mainly for directly life threatening
symptoms like in cancer
tumor therapy.
The novel mechanism of Seek & Heal™ per-
mits use of drug targeting during different circumstances.
As launching base for the technology a product
with minimal registration issues, yet potentially
important has been chosen. The product will
be
used for disinfection of
wounds. |
|
Drug delivery
Drug delivery is a well known concept in pharmaceutical product development.
Two major concepts are outlined:
Drug
release and Drug targeting.
Drug release
Drug release represents an increase of
activity of a pharmaceutical
substance.
A
com
mon area is sustained release, when
the drug slowly
reaches the
surrounding
tissue.
Typical examples include
release from
a capsule or
particle. The gross
concentration
of the drug is not
changed when the drug is
released.
Virtually all projects within drug delivery
are concerned
with drug release.
Drug targeting
Drug targeting represents an increase in
concentration of a pharmaceutical substance
in
an intended target tissue. Concentration enhancement
is different from
drug release
as drug
activity becomes elevated and not
decreased
by actions of the carrier.
Some therapies, marketed as drug
targeting, e.g. release of a
substance
in some
part
of the gastric system, actually represents
release. The total
concentration of the drug
is
not
enhanced during
release.
Common technologies use filtration due to size (EPR effect)
or
ligands
that
attach to
specific molecules
on the
target tissue.
|
|