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Antibiotic resistance
Wound infections
Antimicrobial peptides
Seek & Heal™ targeting
Targeting verification
Antimicrobial substance
Bactericide verification
Tissue friendly verification
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Antimicrobial Peptides - AMPs



Antimicrobial peptides (AMPs) form an early defense
against invading microorganisms.

AMPs have been studied extensively during the last
15 years, see e.g."Antimicrobial Peptides and Human
Disease" by Shafer (Springer 2005).

Some commercially available peptides related to AMPs
are Nisin, Gramicidins and Polymyxins.


One of several AMPs is LL-37. It is produced by
epithelial cells and in circulating blood cells.

Problems with LL-37 include that the peptide strikes
unselectively against both pathologic microorganisms
and the patient’s own cells.

Use of Seek & Heal™ targeting to target pathologic
organisms therefore was expected to increase usa-
bility of the peptide.

Project status

Due to an unfavorable price-to- performance profile of
LL-37, substances other than LL-37 are today incorpo-
rated in products using Seek & Heal™ targeting.


   Amino acid color codes
not polar, hydrophobic
aromatic hydrophobic
aromatic hydrophobic polar
acidic (anionic)
polar uncharged
basic (i.e. cationic)
basic aromatic



LL-37 in surface chemical and cartoon view.
Structure from Li, X. et al., J. Am. Chem. Soc.128
(2006) 5776.