Cytostatic action
Seek & Heal™ targeting
Neoplastic cells, e.g. cancer tumors and
metastases, use metabolism paths different from human normal tissue cells.
One of these paths is used in Seek& Heal™ targeting.
Seek & Heal™ particles, containing a cytotoxic substance, adhere to neoplastic
cells. The particles are then degraded, and high concentrations of
cytotoxic substance are liberated close
to the neoplastic cell. The cancer cell is
killed without damages human healthy
tissues.
The in vitro results show high potency
of the cytotoxic substance, comparable
to what is published in literature for
not encapsulated substance.
The results indicate that Seek&Heal™
targeting can be used during chemotherapy. The technology
may also solve the important problem of
finding metastases that are too
small to be detected using present
techniques. |
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Experimental details and results
Using standard experimental methods, the efficacy of the
Seek & Heal™ targeting formulation E76 in killing cancer
cells was investigated in collaboration
with Spago Imaging AB.
Four different cell lines were used in the tests:
• two types of prostate cancer
• one type of liver
cancer
• one type
of breast
cancer
The results are summarized below.
Due to variation in the experimental results, the averages of
data from all cell types are given in the figure below. |
